Kambo has been in use for a long time

Kambo, a venemous secretion of the phyllomedusa bicolor frog of the Amazon, has been used for centuries by indigenous, Pano-speaking tribes and peoples which include the Katukina, Asháninka, Yaminawá, Matsés and even, potentially, the ancient Mayans.

The tribal, medicinal uses of Kambo were to treat the illnesses which arise from within the Amazon:

• Malaria
• Viral, and Bacterial Infections
• Fevers
• Fertility Difficulties
• Lowering Bodily Pain and Inflammation

Why does Kambo work?

Italian scientist, Vittorio Erspamer, was the first scientist to analyze Kambo in a lab.

Erspamer concluded that Kambo contains a ‘fantastic chemical cocktail with potential medical applications, unequalled by any other amphibian’.

Peptides prove Kambo works

The peptides in Kambo, most notably including phyllocaerulein, phyllomedusin, phyllokinin, sauvagine, dermaseptin B2, adenoregulin, deltorphins, and dermorphin contribute to what make Kambo a natural healing remedy.

To cite Vittorio Erspamer’s 1993 study, “Pharmacological studies of ‘sapo’ from the frog Phyllomedusa bicolor skin…” :

“The dried skin secretion from Phyllomedusa bicolor, ‘sapo’, is used by the Matses Indians of the Northern Peru, in shamanic rites mainly designed to improve luck in hunting. When rubbed into burned, exposed areas of the skin, the drug causes the prompt appearance of violent peripheral gastrointestinal and cardiovascular effects soon followed by remarkable central effects (increase in physical strength, heightening of senses, resistance to hunger and thirst, exalted capacity to face stress situations). All the peripheral and most of the central effects of ‘sapo’ can be ascribed to the exceptionally high content of the drug (up to 7% of its weight) in potently active peptides, easily absorbed through the burned, inflamed areas of the skin. The concentration in ‘sapo’ of the single peptides (phyllocaerulein, phyllomedusin, phyllokinin, demorphins and deltorphins) has been determined by bioassay, and peptide contents were correlated with the different symptoms of the ‘sapo’ intoxication.”


Some of these active peptides are those listed below:


The primary peptides responsibly for the pain inhibiting affects of Kambo, including their appetitie management effects, are the peptides:

• Phyllocaerulein (Shown Below)
• Deltorphins
• Dermophin


The primary peptides responsibly for the behavioral change, including treatment of depression and additions along with the enhancement of energy, are the peptides:

• Phyllomedusin
• Phyllokinin
• Sauvagine
• Adenoregulin


The primary peptides responsibly for the anti-bacterial and anti-viral affects of Kambo, are the peptides:

• Dermaseptin B2
• Sauvagine